Medication: Amoxicillin-clavulanate

Your cat has been prescribed amoxicillin-clavulanate for the treatment of a bacterial infection. This medication is often used to treat skin infections, dental infections, urinary tract infections, respiratory infections and enteritis (infections of the intestine associated with diarrhea).

Key points:
• Antibiotic.
• Dosage: twice daily.
• Should not be handled by people with allergies to penicillins or cephalosporins.

This information sheet is designed to help answer commonly asked questions and help you give the medication safely and effectively to your pet. It does not contain all available information for this medication. If you have other questions or need more information, contact your veterinarian or pharmacist.Always follow the dosing instructions provided by your veterinarian.

Human dosage forms contain varying amounts of clavulanic acid and are not interchangeable with veterinary dosage forms. Veterinary-labeled dosage forms contain amoxicillin and clavulanate in a fixed ratio of 4:1, respectively, and are often labeled for strength as the combination.

Name

• Amoxicillin-clavulanate (A- mox-i-sih-lin – clav-yoo-la-nayt) or amoxicillin-clavulanic acid.

Brand name

• Cladaxxa 200 mg/50 mg Chewable tablets for cats and dogs (UK).
• Cladaxxa 40 mg/10 mg Chewable tablets for cats and dogs (UK).
• Cladaxxa 400 mg/100 mg Chewable tablets for dogs (UK).
• Clamoxyl Palatable Tablets 200 mg (UK).
• Clamoxyl Palatable Tablets 40 mg (UK).
• Clavaseptin 250 mg Palatable tablets for dogs (UK).
• Clavaseptin 50 mg Palatable tablets for dogs and cats (UK).
• Clavaseptin 500 mg Palatable tablets for dogs (UK).
• Clavaseptin 62.5 mg Palatable tablets for dogs and cats (UK).
• Clavaseptin 750 mg Palatable tablets for dogs (UK).
• Clavubactin 250/62.5 mg Tablets for dogs (UK).
• Clavubactin 50/12.5 mg Tablets for cats and dogs (UK).
• Clavubactin 500/125 mg Tablets for dogs (UK).
• Clavucil 200 mg/50 mg Tablets for dogs (UK).
• Clavucil 40 mg/10 mg Tablets for dogs and cats (UK).
• Clavucil 400 mg/100 mg Tablets for dogs (UK).
• Clavudale 200 mg/50mg Tablets for dogs (UK).
• Clavudale 40 mg/10mg Tablets for dogs and cats (UK).
• Clavudale 400 mg/100mg Tablets for dogs (UK).
• Kesium 200 mg/50 mg Chewable Tablets for dogs (UK).
• Kesium 40 mg/10 mg Chewable Tablets for cats and dogs (UK).
• Kesium 400 mg/100 mg Chewable Tablets for dogs (UK).
• Kesium 50 mg/12.5 mg Chewable Tablets for cats and dogs (UK).
• Kesium 500 mg/125 mg Chewable Tablets for dogs (UK).
• Noroclav 250 mg Tablets for dogs (UK).
• Noroclav 50 mg Tablets for dogs and cats (UK).
• Noroclav 500 mg Palatable Tablets for dogs (UK).
• Synuclav 250 mg Tablets for dogs (UK).
• Synuclav 50 mg Tablets for dogs and cats (UK).
• Synuclav Palatable Tablets 500 mg for dogs (UK).
• Synulox Palatable Drops, Powder for Oral Suspension (UK).
• Synulox Palatable Tablets 250 mg (UK).
• Synulox Palatable Tablets 50 mg (UK).
• Synulox Palatable Tablets 500 mg (UK).
• Clavamox® Chewable Tablets 62.5 mg (US).
• Clavamox® Chewable Tablets 125 mg (US).
• Clavamox® Chewable Tablets 250 mg (US).
• Clavamox® Chewable Tablets 375 mg (US).
• Clavamox® Drops 62.5 mg/ml (US).
• Clavacillin® 62.5 mg Tablets for dogs and cats (US).
• Clavacillin® 125 mg Tablets for dogs (US).
• Clavacillin® 250 mg Tablets for dogs (US).
• Clavacillin® 375 mg Tablets for dogs (US).
• Clamoxy-VetTM Tablets (US).

Class of medication

• Broad spectrum antimicrobial.

Storage

• Store at 20°C-25°C (68°F-77°F).
• Oral liquids must be stored in the refrigerator and are stable for 10 days after mixing.

Your veterinarian has prescribed amoxicillin-clavulanate for the treatment of infections caused by one or more of the following bacteria:

• Staphylococcus aureus. 
• β-lactamase producing Staphylococcus aureus. 
• Staphylococcus epidermidis.
• Staphylococcus intermedius.
• Streptococcus faecalis.
• Streptococcus spp.
• Corynebacterium pyogenes.
• Corynebacterium species.
• Erysipelothrix rhusiopathiae.
• Bordetella bronchiseptica.
• Escherichia coli.
• Proteus mirabilis.
• Proteus spp.
• Enterobacter spp.
• Klebsiella pneumoniae.
• Salmonella Dublin.
• Salmonella typhimurium.
• Pasteurella multocida.
• Pasteurella haemolytica.
• Pasteurella spp.

Amoxicillin-clavulanate is given orally (as tablets or in liquid form). It is administered twice daily. Tablets and liquid can either be administered directly into your cat’s mouth or along with some food. The liquid should be well-shaken before withdrawing a dose from the bottle.

Many amoxicillin-clavulanate tablets and liquids are very palatable, so be sure to keep them out of your cats reach.

Very rarely, hypersensitivity reactions (allergic reactions) may occur. If this happens, stop the treatment and contact your veterinarian immediately.

Amoxicillin-clavulanate should not be used in animals that have previously had an allergic reaction to any penicillin or cephalosporin antibiotics.

Some amoxicillin and clavulanic acid preparations are marketed as being suitable for use in pregnant and lactating animals.

This medication should be used cautiously in animals with liver or kidney disease.

Anorexia (reduced appetite), lethargy (tiredness), vomiting and diarrhea are possible side effects of amoxicillin-clavulanate and should be reported to your veterinary surgeon. Cats who go for long periods without eating anything are at risk for liver disease, so contact your veterinary surgeon if your cat stops eating. Your pet may be able to continue with the drug, if side effects are mild, but it’s best to let your veterinarian know as soon as possible, so that they can decide whether additional medications or different medications are required.

Amoxicillin-clavulanate tablets or liquids should be administered according to your veterinarian’s instructions. The treatment course usually extends for 5-7 days, or for 48hrs after the resolution of clinical signs. If no improvement is seen within 5 days, your veterinarian may recommend a different course of therapy.

Urinary tract infections and chronic skin infections may require extended courses of treatment of up to 30 days.

Dispose of any unused amoxicillin-clavulanate safely – do not flush down the toilet or sink. Ask your veterinary team if they take back medication for disposal. Do not save amoxicillin-clavulanate for future use or give to other pets.

If you miss a dose, give the dose as soon as possible but do not give a double dose. Make sure the dose given does not exceed the total recommended dose in any 24-hour period.

If your pet is unwell, contact your veterinarian for advice.

Amoxicillin-clavulanate should only be given to the cat that it has been prescribed for. If accidentally given to other pets, contact your veterinarian for advice.

This medication in contraindicated for use in rabbits, guinea-pigs, rats, mice, hamsters and gerbils and may cause a fatal diarrhea in these species. Contact your veterinarian for advice if one of these species accidentally consumes this medication.

If accidentally consumed by a human, speak to your primary care physician or poison control center. Amoxicillin-clavulanate can cause allergic reactions in humans sensitized to penicillin and cephalosporin antibiotics.

No specific tests are required while your cat is taking amoxicillin-clavulanate.

Further information

If you have any concerns, further information on amoxicillin-clavulanate can be found on the package insert and the following websites:

Europe & UK

• Krka (UK) Cladaxxa chewable tablets for cats and cats. Website: www.noahcompendium.co.uk/?id=-480089​.
• Vetoquinol (UK) Clavaseptin. Website: www.noahcompendium.co.uk/?id=-459266​.
• Dechra (UK) Clavubactin® Tablets. Website: www.noahcompendium.co.uk/?id=-475264&fromsearch=true#iosfirsthighlight.
• Chanelle Pharma (UK & Europe) Clavucill. Website: www.noahcompendium.co.uk/?id=-449106.
• Dechra (UK) Clavudale® Tablets. Website: www.noahcompendium.co.uk/?id=-449556&fromsearch=true#iosfirsthighlight.
• Ceva (UK) Kesium. Website: www.noahcompendium.co.uk/?id=-448386.
• Norbrook (UK) Noroclav 500mg Tablets. Website: www.noahcompendium.co.uk/?id=-471550&fromsearch=true#iosfirsthighlight​
• MiPet (UK) Synuclav 50mg Tablets. Website: www.mipet.com/mipet-synuclav-50mg-tablets-pack-100.html​.
• Zoetis (UK) Synulox Palatble Tablets 50mg and 250mg. Website: www.noahcompendium.co.uk/?id=-458482​.

US

• Zoetis (US) Clavamox Chewable. Website: www2.zoetisus.com/content/pages/products/petcare/Clavamox-Resources/documents/Clavamox-chewable-drops-marketing-package-inserts.pdf​
• Dechra (US) Clavacillin^TM Website: www.dechra-us.com/Files/Files/SupportMaterialDownloads/us/clavacillin_detailer.pdf​.

Always follow the recommended dosage and contact your veterinary team or pharmacist if you have any questions regarding your cat’s medication.